Welcome to Biofuels Institute of Jiangsu University !

Home > > Research Highlight > > Content
Home
Research Highlight

​Prof. Liu's group Published article on International Journal of Biological Macromolecules with the title of "Biosafety consideration of nanocellulose in biomedical applications: A review"

By :    Date : 2024-05-22 13:53:42    View :

Prof. Liu's group Published article on International Journal of Biological Macromolecules  with the title of "Biosafety consideration of nanocellulose in biomedical applications: A review"


A B S T R A C T

Nanocellulose-based biomaterials have gained significant attention in various fields, especially in medical and pharmaceutical areas, due to their unique properties, including non-toxicity, high specific surface area, biodegradability, biocompatibility, and abundant feasible and sophisticated strategies for functional modification. The biosafety of nanocellulose itself is a prerequisite to ensure the safe and effective application of biomaterials as they interact with living cells, tissues, and organs at the nanoscale. Potential residual endogenous impurities and exogenous contaminants could lead to the failure of the intended functionalities or even serious health complications if they are not adequately removed and assessed before use. This review summarizes the sources of impurities in nanocellulose that may pose potential hazards to their biosafety, including endogenous impurities that co-exist in the cellulosic raw materials themselves and exogenous contaminants caused by external exposure. Strategies to reduce or completely remove these impurities are outlined and classified as chemical, physical, biological, and combined methods. Additionally, key points that require careful consideration in the interpretation of the biosafety evaluation outcomes were discussed to ensure the safety and effectiveness of the nanocellulose-based biomaterials in medical applications.


https://doi.org/10.1016/j.ijbiomac.2024.130900


Last :Prof. Liu and Prof. Sun's group Published article on Industrial Crops & Products with the title of "Sawdust-derived cellulose nanofibrils with high biosafety for potential bioprinting"

Next :Prof. Liu's group Published article on Carbohydrate Polymers with the title of "A structure-functionality insight into the bioactivity of microbial polysaccharides toward biomedical applications: A review "